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Mca01-008

Effects of Arylsulfatase B and Pembrolizumab in Combination on Progression of Metastatic Melanoma in the B16F10 Syngeneic Mouse Model

Quote:In this report, we show how treatment by recombinant human ARSB and Pembrolizumab lead to increased apoptosis, declines in expression of metalloproteinases MMP2 and MMP9 and in invasiveness, and altered cytokine/chemokine expression. The synergism between ARSB and Pembrolizumab may affect the progression of melanoma and improve treatment outcomes.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.02.25343295v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.02.25343295v1.full-text
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Search Authors: Sumit Bhattacharyya Insug O-Sullivan Joanne Tobacman, 
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Mca01-024

Extracellular vesiclederived urinary metabolomes show distinctive changes with breast cancer

Quote:Conclusions The whole urine and EV metabolomes suggested a small number of metabolite changes that were specific to BC. This could indicate that the urinary EVs describe distinctive aspects of the breast carcinogenic process.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.05.26343426v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.05.26343426v1.full-text
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Search Authors: Anuradha U K H Bambarandhage Nur Aimi Aliah Zainurin Noura Laziri Tim Gate Helen Tench Manfred Beckman Helen Phillips Russell Morphew Mandana Pennick Luis A J Mur, 
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Mpt01-022

Search and Retrieval in Dermatology Atlases of Histopathology Images for Risk Stratification of Cutaneous Squamous Cell Carcinoma

Abstract: https://www.medrxiv.org/content/10.64898/2026.01.02.26343356v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.02.26343356v1.full-text
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Search Authors: Ghazal Alabtah Areej Alsaafin Saghir Alfasly Abubakr Shafique Sobhan Hemati Anirudh Choudhary Ravishankar K. Iyer David DiCaudo Steve Nelson Alyssa Stockard Zach Leibovit-Reiben Nan Zhang Krishna R. Kalari Dennis Murphree Aaron Mangold Nneka Comfere H.R. Tizhoosh, 

  Updated weekly. 01/09/2026-11:01:09 PM
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