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    PAIN   

Mor01-022

Intradiscal propionic acid levels in chronic low back pain patients with Modic type 1 changes are associated with systemic immune cell activation

Quote:Conclusion Intradiscal PA, measurable non-invasively by MRS, stratifies MC1 patients into biologically distinct subgroups characterised by systemic B cell activation. These findings suggest a systemic immune component to MC1 pathobiology and highlight B cells as candidate biomarkers and therapeutic targets for MC1-related chronic low back pain.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.06.26343445v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.06.26343445v1.full-text
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Search Authors: Jan Devan Jiamin Zhou Po-Hung Wu Noah Bonnheim Conor ONeill Jeffrey C. Lotz Thomas M. Link Abel Torres-Espin Stefan Dudli Aaron J. Fields span classnlm-collab data-hwp-idcollab-1the REACH Center at UCSF, 

  Updated weekly. 01/09/2026-11:01:09 PM
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