Research
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Scanned: 2759
Evaluated: 288
Selected: 68

 
    PRIME    AGING    BRAIN    COGNITION    PHYSICAL   

Mne03-020

Physical fitness supports brain maintenance and cognitive reserve in cognitively normal aging: a cross-sectional examination

Quote:Conclusion Muscular capacity was linked to lower BG PVS volumes, supporting resistance against pathology, while aerobic fitness related to preserved cortical integrity and tended to act as a CR proxy against MTL tau pathology. Physical fitness may support cerebrovascular and glymphatic function, thereby promoting cognitive resilience and extending healthspan by sustaining functional brain health and mitigating tau-related cognitive decline.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.14.26344098v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.14.26344098v1.full-text
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Search Authors: Svenja Schwarck Niklas Behrenbruch Beate Schumann-Werner Ein N. Molloy Berta Garcia-Garcia Anne Hochkeppler Larissa Fischer Anna-Therese Bchel Enise I. Incesoy Jose Bernal Roberto Duarte Coello Maria d.C. Valds-Hernndez Joanna M. Wardlaw Niklas Vockert Patrick Mller Gusalija Behnisch Barbara Morgado Hermann Esselmann Constanze I. Seidenbecher Bjrn H. Schott Henryk Barthel Osama Sabri Jens Wiltfang Michael C. Kreissl Emrah Dzel Anne Maass, 
    AGING    BRAIN    COGNITION   

Mne03-030

Lifelong trajectories of modifiable vascular risk factors and relation to cerebral small vessel disease in the Framingham Heart Study

Quote:Conclusions Individuals following high risk lifetime patterns of vascular risk factors have higher CSVD burden later in life. These results highlight the importance of primordial and primary prevention with sustained risk factor management across the lifespan to mitigate CSVD burden, a strong determinant of stroke and dementia risk.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.16.26344309v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.16.26344309v1.full-text
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Search Authors: Jose R. Romero Adlin Pinheiro Serkalem Demissie Hugo J. Aparicio Vasileios-Arsenios Lioutas Antreas Charidimou Alexa Beiser Oluchi Ekenze Jayandra J. Himali Charles DeCarli Sudha Seshadri Shariq Mohammed, 
Search Words:
Cerebral small vessel disease CSVD Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    AGING    COGNITION    PSYCHOLOGY   

Mpy03-016

Exploring reward learning disruptions as a possible mechanism underlying neuropsychiatric symptoms in Parkinsons disease

Quote:Conclusions We found inconsistent relationships between symptoms of apathy, depression, and impulsivity and reward learning performance across two samples of PD patients. While this doesnt rule out the possibility that reward learning impairments contribute to these symptoms, it suggests any effect is likely to be small and overshadowed by other non-measured factors.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.14.26344132v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.14.26344132v1.full-text
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Search Authors: Sophie Sun Madeleine Sharp, 
    AGING    BRAIN    COGNITION    SLEEP   

Mpy03-022

Cross-sectional and longitudinal associations between sleep disturbances and psycho-affective symptoms in older adults: influence of amyloid positivity

Quote:Conclusions: In cognitively unimpaired older adults, associations between sleep disturbances and psycho-affective symptoms differ according to A#946; status. In A#946; individuals specifically, objective sleep fragmentation and instability are linked to psycho-affective vulnerability and brooding worsening over time. Sleep disturbances could thus represent early modifiable targets to mitigate psycho-affective symptomatology in older adults.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.15.26344227v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.15.26344227v1.full-text
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Search Authors: Claire Andr Edelweiss Touron Antoine Garnier-Crussard Andre-Ann Baril Gal Chtelat Sophie Dautricourt Natalie L. Marchant Graldine Rauchs span classnlm-collab data-hwp-idcollab-1Medit-Ageing Research Group, 

  Updated weekly. 01/24/2026-02:51:25 AM
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