PRIME DIABETES HEART NUTRITION
Aab04-002	High Dose NAC
	Quote:	Boosts glutathione production. 600mg low dose long term support. 1200mg 30 - 90 dayshelps overcome issues. 14 days, 2,000 aggressive support of healing. not every supplement is right for every person.
	Comment:	Some MCS victems swear by it. Not all benefit from it. it jsut depends where you are biochemically broken inside.
	Article:	http://youtube.com/watch?v9foOavZyLrg
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PRIME HEART NUTRITION
Aab04-005	The Study Cardiology Willfully Ignored for Over Two Decades
	Quote:	In the pomegranate group, mean IMT at baseline was 1.5 mm. What they observed over the following year was a progressive, stepwise regression: At three months: 13 percent reduction in IMT. At six months: 22 percent reduction. At nine months: 26 percent reduction. At twelve months: up to 35 percent reductionwith mean IMT dropping from 1.5 mm to 1.1 mm.
	Article:	https://principia-scientific.com/the-study-cardiology-willfully-ignored-for-over-two-decades/
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DIAGNOSTICS HEART TECH
Mcr04-004	A Wearable Multi-modal Sensor Array for Continuous Cuffless Blood Pressure Estimation
	Quote:	From these input data, we extract cardiovascular timing intervals e.g., pulse arrival time, which serve as key features for BP regression models, enabling continuous, non-invasive BP monitoring.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.01.25.26344788v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.01.25.26344788v1.full-text
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	Search Authors:	John Rattray Bright Nnadi Sampath Rapuri Carl W Harris Francesco Tenore Charlene Gamaldo Robert D Stevens Ralph Etienne-Cummings,
PRIME PRIO HEART NUTRITION
Mcr04-016	Monosodium Urate Crystals within Cardiomyocytes
	Quote:	Conclusion: This study provides conclusive morphological, chemical, and crystallographic evidence of intracardiac MSU deposition in gout. It directly links myocardial crystal accumulation to diastolic dysfunction, proposing uric acid cardiomyopathy as a novel disease entity. Collectively, these findings achieve a paradigm shift in the perception of gout, redefining it from a peripheral arthropathy to a systemic disorder capable of causing direct myocardial injury.
	Comment:	Dr. Cathcart said that high dose vitamin C almost always lowered uric acid levels, because raising uric acid levels is one way our body creates anti-oxidants that it percieves it needs for some reason.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.01.20.26344247v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.01.20.26344247v1.full-text
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	Search Authors:	Jiangwei Ma Jing Tan Conghui Shen Tingting Mai Ludong Yuan Teng Wu Shijie Xiong Tongsheng Huang Yuanjun Ji Mengying Liu Maoquan Yang Erwen Huang Weibin Cai,
GENETICS HEART
Mcr04-028	Epigenetics in Abdominal Aortic Aneurysm: Mechanisms and Risk Prediction
	Quote:	Conclusions This study identified putative causal DNA methylation markers for AAA, and multi-omics analyses implicate AP-1linked inflammatory transcriptional programs, blood lipids, platelet count, and multiple immune/inflammation-related proteins as key pathways underlying methylation-associated AAA risk.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.01.26.26344463v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.01.26.26344463v1.full-text
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	Search Authors:	Shuai Yuan Gabrielle Shakt Michael Levin Katherine Hartmann Renae Judy Tia Dinatale Amy Voorhees Julie A. Lynch Saiju Pyarajan Daniel Levy Roby Joehanes span classnlm-collab data-hwp-idcollab-1VA Million Veteran Program Kyong-Mi Chang Philip Tsao Benjamin F. Voight Gregory T Jones Scott M. Damrauer,
DENTAL HEART
Mde04-014	Multi-domain Identification of Myocardial Infarction Incidence using Explainable AI: The Overlooked Role of Periodontal Health
	Quote:	. Additionally, individual-level waterfall plots illustrated how oral inflammation may contribute independently or in combination with conventional factors to MI incidence identification. These findings support a systems-level view of periodontitis as a modifiable, biologically relevant factor in cardiovascular health and underscore the value of considering oral-health markers within screening and management frameworks.
	Abstract:	https://www.medrxiv.org/content/10.64898/2025.12.18.25342537v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2025.12.18.25342537v1.full-text
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	Search Authors:	Moemen Hussein Lu Li Karen L. Falkner Michael J. Buck Patricia I. Diaz Haralampos Hatzikirou,
HEART METABOLISM
Mep04-038	ASSOCIATION ANALYSIS OF MITOCHONDRIAL HETEROPLASMIC VARIANTS AND CARDIOMETABOLIC TRAITS
	Quote:	Mitochondrial heteroplasmic variant has been increasingly recognized as a potential contributor to common complex diseases, ... We identified twelve significant gene-trait associations after Bonferroni correction, with consistent effect directions across coding definitions. The strongest association was observed between hyperlipidemia and heteroplasmic variants in CO1 gene OR0.28, 95 CI0.17, 0.46, p3.4E-7 among EA European Americans. Additional associations were detected for BMI, adjusted SBP systolic blood pressure, BG blood glucose, diabetes, and adjusted LDL. These findings highlight the contribution of heteroplasmic variation within mtDNA to cardiometabolic phenotypes and provide new insight into mitochondrial involvement in CMD pathophysiology.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.01.23.26344724v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.01.23.26344724v1.full-text
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	Search Authors:	Xianbang Sun Xue Liu Katia Bulekova Achilleas N Pitsillides Xiuqing Guo Yong Qian Laura M Raffield Jerome I Rotter Stephen S Rich Goncalo Abecasis April P Carson Ramachandran S Vasan Joshua C Bis Bruce M Psaty Eric Boerwinkle Annette L Fitzpatrick Claudia L Satizabal Dan E Arking Jun Ding Daniel Levy span classnlm-collab data-hwp-idcollab-1TOPMed mtDNA working group Chunyu Liu,
HEART
Mga04-024	Comparative Effectiveness and Cardiovascular Outcomes of Infliximab reference product and Biosimilars in Patients with Inflammatory Bowel Disease
	Quote:	Conclusion Our study found comparable effectiveness between IFX-RP and IFX-BP in routine clinical care. While cardiovascular events were infrequent, the potential signal suggesting increased MACE risk associated with infliximab biosimilars warrants further investigation. Continued pharmacovigilance is essential to ensure the cardiovascular safety of biosimilars.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.01.25.26344807v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.01.25.26344807v1.full-text
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	Search Authors:	Amirah H. Alnahdi Naueen Chaudhry Alaa Alshehri Qing Liu Mikael Svensson Ellen M. Zimmermann Tianze Jiao,
HEART
Mge04-006	Pharmacogenomic architecture of antihypertensive switching implicates neurotensin-NTSR1 signaling in ACE inhibitor-induced cough
	Quote:	Early failure of antihypertensive medication treatment affects one in four patients, but the underlying mechanisms are poorly understood. We aimed to identify genetic determinants of antihypertensive treatment failure within the first year.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.01.26.26344813v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.01.26.26344813v1.full-text
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	Search Authors:	Felix Vaura Kristi Krebs Tuomo Kiiskinen Joel Rm Max Tamlander span classnlm-collab data-hwp-idcollab-1FinnGen span classnlm-collab data-hwp-idcollab-2Estonian Biobank research team Simone Rubinacci Lili Milani Samuli Ripatti,
HEART IMMUNE
Mrh04-002	The ALDH4A1/anti-ALDH4A1 axis as a novel player of atherosclerosis in rheumatoid arthritis
	Quote:	Conclusions: The ALDH4A1/anti-ALDH4A1 axis emerges as a novel player bridging lipid disturbances and atherosclerosis along the RA spectrum, hence highlighting the involvement of mitochondrial targets. These components hold promise as functional players, clinical tools and therapeutic targets.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.01.21.25342366v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.01.21.25342366v1.full-text
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	Search Authors:	Daniel Miranda-Prieto Mercedes Alperi-Lopez Angel I Perez-Alvarez Roxana Coras Sara Alonso-Castro Nuria Amigo Monica Guma Ana Suarez Javier Rodriguez-Carrio,

Updated weekly. 01/31/2026-02:32:41 AM
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What interests you?

Aab04-002

High Dose NAC

Aab04-005

The Study Cardiology Willfully Ignored for Over Two Decades

Mcr04-004

A Wearable Multi-modal Sensor Array for Continuous Cuffless Blood Pressure Estimation

Mcr04-016

Monosodium Urate Crystals within Cardiomyocytes

Mcr04-028

Epigenetics in Abdominal Aortic Aneurysm: Mechanisms and Risk Prediction

Mde04-014

Multi-domain Identification of Myocardial Infarction Incidence using Explainable AI: The Overlooked Role of Periodontal Health

Mep04-038

ASSOCIATION ANALYSIS OF MITOCHONDRIAL HETEROPLASMIC VARIANTS AND CARDIOMETABOLIC TRAITS

Mga04-024

Comparative Effectiveness and Cardiovascular Outcomes of Infliximab reference product and Biosimilars in Patients with Inflammatory Bowel Disease

Mge04-006

Pharmacogenomic architecture of antihypertensive switching implicates neurotensin-NTSR1 signaling in ACE inhibitor-induced cough

Mrh04-002

The ALDH4A1/anti-ALDH4A1 axis as a novel player of atherosclerosis in rheumatoid arthritis