Research
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war-confl
 
Scanned: 2706
Evaluated: 166
Selected: 52

 
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Mca06-002

Prognostic Significance of Cerebrospinal Fluid Glucose, Protein, and White Blood Cell Count in Breast Cancer Leptomeningeal Disease

Quote:When stratified by CSF cytology results and CSF glucose levels, the CSF cytology negative, glucose-low group was associated with the worst OS, while the CSF cytology negative, normal/high glucose group was associated with the best OSp0.03 in an unadjusted analysis. Multivariate analysis confirmed that low CSF glucose was independently associated with poorer survival
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.07.26345775v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.07.26345775v1.full-text
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Search Authors: Sugam Gouli Sujan Niraula Andrea Baran Huina Zhang Ruth ORegan Nimish Mohile Carey K Anders Sara Hardy Ajay Dhakal, 
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Mca06-004

Comparing an AI test to a 21-gene assay for premenopausal node-positive HR /HER2-breast cancer

Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345771v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345771v1.full-text
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Search Authors: Jailan Elayoubi Cerise Tang Kathryn J. Ruddy Khalil Choucair Kevin Kalinsky Katarzyna Pogoda Francisco J. Esteva Jad M Abdelsattar Virginia F Borges Ken Zeng Joseph Cappadona Bartosz Machura Dhruva Biswas Krzysztof J. Geras Jan Witowski, 
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Mca06-006

GALEAS Bladder Demonstrates High Sensitivity and Specificity for Detecting Bladder Cancer: Real-World Multicentre Data from UK NHS Haematuria Clinics

Quote:Conclusions and Clinical Implications GALEAS Bladder is a clinically implementable molecular urine test with very high sensitivity and specificity for the diagnosis of new cases of BC in patients undergoing urgent investigation of haematuria, especially for high-grade BCs. Clinical adoption could permit the molecular triage of haematuria patients to immediate or deferred cystoscopy.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345752v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345752v1.full-text
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Search Authors: Lee Silcock Robert K Hastings Samuel Clokie Rebecca Sadler Michael Parks Matthew Smith Victoria Hewitt Jayne Louise Douglas-Moore Helena Wignall Hugo Escabelado John Piedad Sagar Kanabar Chris Blick Amar Mohee Niall Pumfrey Nadine Coull Andy Goffe Richard Tippett Alexander Laird Chandrarajan Premal Shah Murray MacKay Catherine Owen Uwais Mufti Douglas G Ward Richard T Bryan, 
    AI-CHAT    CANCER    HEART   

Mcr06-014

Multimodal Machine Learning Reveals the Genomic and Proteomic Architecture of Heart Failure with Preserved Ejection Fraction

Abstract: https://www.medrxiv.org/content/10.64898/2026.02.07.26345811v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.07.26345811v1.full-text
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Search Authors: Jack W OSullivan Taedong Yun Ruoyi Cai David Amar Themistocles L Assimes Akshay Chaudhari Dan S Kim Eldrin F Lewis Francois Haddad Farhad Hormozdiari John Weston Hughes Gabriel Mannis Michael Salerno Mark Pepin James Pirruccello Jared Wallace Howard Yang Manuel A Rivas Andrew W Carroll Cory McLean Euan A Ashley, 
    PRIME    CANCER    GUT    MICROBIOME   

Mep06-006

Gut microbiome and metabolome reveal hormone-related and functional alterations in ER-positive breast cancer: a casecontrol study

Quote:Higher levels of DHEA-sulfate, estriol, and isoflavone phytoestrogen metabolites and lower lignan phytoestrogen metabolites were associated with breast cancer, while circulating estrogens and estrogen-related microbial functions were not. Beyond hormone-related pathways, higher levels of conjugated bile acids and carnitines were also associated with breast cancer. Compared to controls, cases exhibited depletion of Blautia obeum, Alistipes shahii, A. finegoldii, A. putredinis, and Anaerotruncus rubiinfantis, along with reduced abundance of functions related to menaquinol-8 biosynthesis, TCA cycle-related energy metabolism, and NAD salvage, indicating depletion of specific metabolic pathways rather than overall functional diversity. These results indicate a potential etiologic role for host-microbe metabolic interactions in breast cancer that extends beyond estrogen-centered mechanisms and warrants validation in independent cohorts.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345778v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345778v1.full-text
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Search Authors: Ashley H Larnder Kristin Campbell Thaddeus J Edens Julian J Lum David R Goodlett Jun Han Kathryn Isaac Rebecca Warburton Michelle Goecke Allen Hayashi Alison Ross Benot Chassaing Maeva Duquesnoy Jessica Morgan Jane Shearer Parveen Bhatti Amee R Manges Rachel A Murphy, 
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Mge06-004

Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of risk

Quote:Integrative analyses of the EwS loci revealed enrichment of expanded GGAA microsatellites, with evidence for binding of the EWSR1::FLI1 chimeric oncogenic activator. EWSR1::ETS knockdown in EwS cell lines resulted in dysregulated genes at susceptibility loci related to skeletal/muscle development, RNA binding/processing, and chromatin regulation.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345779v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345779v1.full-text
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Search Authors: Aubrey K. Hubbard Hlne Neyret-Kahn Martina Mller-Nurasiyd Dominik Lw Konstantin Strauch Olivia W. Lee Andrew R. Raduski Tianzhong Yang Weiyin Zhou Elliot W. Stratton Orson Jay Sandrine Grossette Andrew J. Song Diptavo Dutta Amy A. Hutchinson Belynda D. Hicks Michelle Manning Jia Liu Carrie Boyce Wolfgang Hartmann Uta Dirksen Andreas E. Kulozik Markus Metzler Manuela Krumbholz Alexander Teumer Henry Vlzke Uwe Vlker Joshua D. Schiffman Javed Khan Melissa M. Hudson Kirsten K. Ness Zhaoming Wang Katherine A. Janeway Philip J. Lupo Logan G. Spector Wen-Yi Huang Steven C. Moore Stephen J. Chanock Thomas G.P. Grnewald Olivier Delattre Mitchell J. Machiela, 

  Updated weekly. 02/13/2026-07:20:23 PM
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