PRIME AGING COGNITION HEART
Mph06-002	A Novel Drug-Drug Interaction: Dihydropyridine Calcium Channel Blockers Amplify Gabapentin-Associated Dementia Risk
	Quote:	Conc: Conclusions We identified a novel drug-drug interaction whereby DHP CCB co-medication amplifies gabapentin-associated dementia risk, confirmed by time-varying analysis Rate Ratio1.65. The DHP-specific signal is biologically plausible given independent evidence that DHP CCBs may adversely affect cognition DREAM consortium, while the absence of interaction with verapamil aligns with its potential neuroprotective properties identified in drug repurposing studies. The F03-specific pattern suggests drug-induced cognitive impairment that may be reversible. These hypothesis-generating findings identify gabapentin-DHP CCB combinations as a target for cognitive safety monitoring and warrant confirmation with concurrent exposure measurement
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.06.26345763v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.06.26345763v1.full-text
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	Search Authors:	James W Green Suril Gohel Barbara Tafuto Luciana Mascarenhas Fonseca Michal Schnaider Beeri Sharon Sanz Simon James Scott Parrott Branimir Ljubic Michael Schulewski,
PRIME ARTS BRAINWAVE COGNITION
Mpy06-008	Abnormal hippocampo-cortical theta-gamma phase-amplitude coupling in Alzheimers disease
	Quote:	INTRODUCTION Cognitive decline in Alzheimers disease AD may arise not only from neuronal loss but also from disrupted temporal coordination across distributed networks. Prior works in healthy individuals has shown memory-related modulation of hippocampalcortical phaseamplitude coupling PAC. We hypothesized alteration of resting-state hippocampo-cortical PAC in AD which relates to cognitive impairment.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.06.26345635v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.06.26345635v1.full-text
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	Search Authors:	Erfan Baradarantohidi Srikantan Nagarajan Kamalini Ranasinghe Stefan Haufe,
PRIME AGING BRAIN COGNITION PSYCHOLOGY
Mpy06-020	Functional MRS uncovers age-related alterations in cerebral lactate dynamics during emotional-cognitive engagement, revealing metabolic vulnerability in the dACC
	Quote:	Introduction Lactate plays dual roles in neuronal energy metabolism and signalling. The dorsal anterior cingulate cortex dACC, a region with high baseline glycolytic activity implicated in psychiatric disorders, may exhibit dynamic lactate responses to graded cognitive-emotional demands. Because mitochondrial function declines with age, aging may model whether fMRS-derived lactate dynamics can detect latent neurometabolic vulnerabilities. ... establishes a metabolic stress-testing paradigm for detecting latent neuroenergetic vulnerabilities, supporting fMRS utility for probing mitochondrial function in health and psychiatric disorders.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.05.26345665v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.05.26345665v1.full-text
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	Search Authors:	Edward Caddye Joel Patchitt Anouk Schrantee William T Clarke Itamar Ronen Alessandro Colasanti,

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Mph06-002

A Novel Drug-Drug Interaction: Dihydropyridine Calcium Channel Blockers Amplify Gabapentin-Associated Dementia Risk

Mpy06-008

Abnormal hippocampo-cortical theta-gamma phase-amplitude coupling in Alzheimers disease

Mpy06-020

Functional MRS uncovers age-related alterations in cerebral lactate dynamics during emotional-cognitive engagement, revealing metabolic vulnerability in the dACC