Research
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Scanned: 2653
Evaluated: 237
Selected: 57
 
    BRAIN    COGNITION   

Mne07-004

Quantitative Cerebrovascular Analysis for Improved Prediction of Post-Stroke Complications

Quote:Conclusions: These findings demonstrate that cerebrovascular structure?an often overlooked yet physiologically fundamental determinant of ischemic injury and reperfusion dynamics?provides significant predictive information that is not captured by standard clinical or visual imaging assessments. Automated vascular segmentation and collateral grading techniques enable rapid and objective integration of cerebrovascular metrics into prognostic models, offering a scalable tool for precision risk stratification, supporting earlier intervention, targeted monitoring, and improved post-EVT management.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.12.26346217v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.12.26346217v1.full-text
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Search Authors: Aditi Deshpande Jing Wang Laith Altaweel Seajin Yi Zelalem Bahiru Tahddeus Leiphart Pouya Tahsili-Fahadan Kaveh Laksari, 
    AGING    BRAIN    COGNITION   

Mne07-006

Plasma Proteomic Analysis of APOE 4 Homozygotes Identifies Preclinical Alzheimers Disease Alterations Potentially Treatable with Semaglutide

Quote:emaglutidea GLP-1 receptor agonistdemonstrated reversal effects on metabolic and synaptic pathway alterations in #1013;4 homozygotes at preclinical and clinical AD stages. Targeting metabolic and other pathways for therapeutic intervention in #1013;4/#1013;4 individuals by at least age 50 will likely be the most effective approach to decrease risk for AD in this special population.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.14.26346321v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.14.26346321v1.full-text
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Search Authors: Eric B Dammer Shiva Afshar Shijia Bian span classnlm-collab data-hwp-idcollab-1The Global Neurodegeneration Proteomics Consortium GNPC Allan I. Levey Juan Fortea Erik C.B. Johnson, 
    COGNITION    DIAGNOSTICS   

Mne07-012

Association of infections and autoimmune conditions with cognition: a study using self-reported conditions and identifying a novel plasma biomarker

Quote:Conclusions: In a two-year follow-up, continuous pridopidine treatment in participants remaining off-ADMs was associated with slower clinical progression relative to expected natural-history trajectories. Clinical Trials Identifier: NCT04556656
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.13.26346282v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.13.26346282v1.full-text
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Search Authors: Patrick S Slama Adam R Macbale Bruno M Jedynak, 
    PRIME    AGING    COGNITION   

Mne07-038

Bilingualisms protective effects in Alzheimers disease: Mechanisms of resilience and resistance

Quote:DISCUSSION The protective effects of bilingual experience may engage both resilience and resistance to AD pathophysiology mechanisms. These results underscore the importance of capturing bilingualism in aging cohorts and the study of how lifestyle and sociocultural factors shape the biological expression of neurodegenerative disease.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.13.26345903v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.13.26345903v1.full-text
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Search Authors: Wenfu Bao Stephanie M. Grasso Isabel Sala M. Beln Snchez-Saudins Judit Selma-Gonzlez Javier Arranz Nuole Zhu Sara Rubio-Guerra igo Rodrguez-Baz Mara Carmona-Iragui Isabel Barroeta Ignacio Illn-Gala Juan Fortea Olivia Belbin Ldia Vaqu-Alczar Marco Calabria Eider M. Arenaza-Urquijo Alexandre Bejanin Daniel Alcolea Alberto Lle Miguel ngel Santos-Santos, 
    PRIME    AGING    COGNITION    HEART   

Mph06-002

A Novel Drug-Drug Interaction: Dihydropyridine Calcium Channel Blockers Amplify Gabapentin-Associated Dementia Risk

Quote:Conc: Conclusions We identified a novel drug-drug interaction whereby DHP CCB co-medication amplifies gabapentin-associated dementia risk, confirmed by time-varying analysis Rate Ratio1.65. The DHP-specific signal is biologically plausible given independent evidence that DHP CCBs may adversely affect cognition DREAM consortium, while the absence of interaction with verapamil aligns with its potential neuroprotective properties identified in drug repurposing studies. The F03-specific pattern suggests drug-induced cognitive impairment that may be reversible. These hypothesis-generating findings identify gabapentin-DHP CCB combinations as a target for cognitive safety monitoring and warrant confirmation with concurrent exposure measurement
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345763v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345763v1.full-text
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Search Authors: James W Green Suril Gohel Barbara Tafuto Luciana Mascarenhas Fonseca Michal Schnaider Beeri Sharon Sanz Simon James Scott Parrott Branimir Ljubic Michael Schulewski, 
    PRIME    BRAINWAVE    COGNITION   

Mpy06-008

Abnormal hippocampo-cortical theta-gamma phase-amplitude coupling in Alzheimers disease

Quote:INTRODUCTION Cognitive decline in Alzheimers disease AD may arise not only from neuronal loss but also from disrupted temporal coordination across distributed networks. Prior works in healthy individuals has shown memory-related modulation of hippocampalcortical phaseamplitude coupling PAC. We hypothesized alteration of resting-state hippocampo-cortical PAC in AD which relates to cognitive impairment.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345635v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345635v1.full-text
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Search Authors: Erfan Baradarantohidi Srikantan Nagarajan Kamalini Ranasinghe Stefan Haufe, 
    PRIME    AGING    BRAIN    COGNITION    PSYCHOLOGY   

Mpy06-020

Functional MRS uncovers age-related alterations in cerebral lactate dynamics during emotional-cognitive engagement, revealing metabolic vulnerability in the dACC

Quote:Introduction Lactate plays dual roles in neuronal energy metabolism and signalling. The dorsal anterior cingulate cortex dACC, a region with high baseline glycolytic activity implicated in psychiatric disorders, may exhibit dynamic lactate responses to graded cognitive-emotional demands. Because mitochondrial function declines with age, aging may model whether fMRS-derived lactate dynamics can detect latent neurometabolic vulnerabilities. ... establishes a metabolic stress-testing paradigm for detecting latent neuroenergetic vulnerabilities, supporting fMRS utility for probing mitochondrial function in health and psychiatric disorders.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345665v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345665v1.full-text
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Search Authors: Edward Caddye Joel Patchitt Anouk Schrantee William T Clarke Itamar Ronen Alessandro Colasanti, 

  Updated weekly. 02/20/2026-11:39:18 PM
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