Research
Topics:
INDEX
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brain 12
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unk
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war-confl
 
Scanned: 2629
Evaluated: 248
Selected: 73

 
    AI-CHAT    AGING    HEART   

Mgr12-022

A deep-learning based biomarker of systemic cellular senescence burden to predict mortality and health outcomes

Quote:Results The deep learning-based SASP Score was a strong, independent predictor of mortality risk and incident serious, chronic medical conditions e.g., dementia, COPD, myocardial infarction, stroke. In an independent cohort, multimodal exercise significantly changed the SASP Score trajectory over 18 months. Discussion Our findings support the potential of a deep learning-derived SASP Score as a biomarker for systemic cellular senescence burden. Our statistical approach can offer enhanced interpretability and cross-platform utility, providing a valuable tool for aging research and the evaluation of geroscience-guided interventions.
Abstract: https://www.medrxiv.org/content/10.64898/2026.03.20.26348913v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.20.26348913v1.full-text
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Search Authors: Shangshu Zhao Chia-Ling Kuo Eric J. Lenze Julie L. Wetherell Laura Haynes Perla El-Ahmad Richard Fortinsky George Kuchel Trevor Harris Breno Satler Diniz, 
    HEART    KIDNEYS    NUTRITION   

Mkd12-022

Quality of life in hyperkalemia: baseline analysis of a cohort study of management of hyperkalemia in patients with chronic kidney disease or heart failure in Japan

Quote:Treatment-specific QOL scores indicated that potassium binders had a smaller impact on QOL than dietary therapy. Adherence to potassium binders was high. Conclusions. Concurrent use of RAAS inhibitors and potassium binders was common, suggesting that binders may support RAAS inhibitor continuation. Potassium binders showed less perceived impact than dietary restrictions, indicating that pharmacologic potassium control may be acceptable to patients managing multiple lifestyle limitations.
Abstract: https://www.medrxiv.org/content/10.64898/2026.03.24.26349144v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.24.26349144v1.full-text
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Search Authors: Ken-ei Sada Hajime Yamazaki Takafumi Wakita Yosuke Yamamoto Jui Wang Yoshihiro Onishi Tadateru Hamada Ryotaro Ide Masayoshi Takeda Shinichi Fukuhara Yugo Shibagaki, 
    AGING    BRAIN    COGNITION    HEART   

Mne12-010

Middle aged carotid plaque and cognitive functions in later life: a population-based study. Middle aged carotid plaque and cognitive functions in later life: a population-based study.

Quote:Discussion: In this large cohort study, carotid plaque status at baseline was independently associated with in cognitive function decline, especially in non-verbal memory and executive functioning over 8-year follow-up period in the general population. Therefore, it may be important for earlier intervention on carotid plaque to preserve neurological health in middle-aged to older population.
Abstract: https://www.medrxiv.org/content/10.64898/2026.03.23.26349039v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.23.26349039v1.full-text
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Search Authors: Gisung Shin Ali Tanweer Siddiquee Min-Hee Lee June Christoph Kang Yoonho Hwang Seungku Lee Bongjo Kim Youngjin Kim Chol Shin Nanhee Kim Gisung Shin Ali Tanweer Siddiquee Min-Hee Lee June Christoph Kang Yoonho Hwang Seungku Lee Bongjo Kim Youngjin Kim Chol Shin Nanhee Kim, 
    HEART    NUTRITION   

Mnu12-002

Metabolic Phenotyping Objectively Captures Dietary Intake and Shortterm Cardiovascular Disease Risk Responses Under an Inpatient Randomized Crossover Clinical Trial

Quote:Conclusions Urinary metabolic phenotyping offers a sensitive and non-invasive tool for objectively assessing dietary intake. Short-term adherence to contrasting dietary patterns produced rapid, diet-specific metabolic and microbial effect in individuals at elevated CVD risk and differentially impacted cardiovascular risk profiles. This trial was registered at the ISRCTN registry https://www.isrctn.com/ISRCTN44705179 .
Abstract: https://www.medrxiv.org/content/10.64898/2026.03.20.26348884v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.20.26348884v1.full-text
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Search Authors: Yiwei Wu Lina Alqarni Joram M Posma Melpomeni Kasapi Liam Walsh Orla OSullivan Elaine Holmes Gary Frost Isabel Garcia-Perez, 
    BRAIN    HEART   

Msm12-022

Effects of HIIT and HIIT plus Resistance Training on Cerebral Blood Flow and Other Health Outcomes in Individuals with Coronary Artery Disease: The Heart-Brain Randomized Controlled Trial

Quote:Conclusion: Twelve weeks of HIIT RT or HIIT did not increase CBF in the whole sample with CAD, but HIIT effectively increased CBF in those who had poorer CBF at baseline.
Abstract: https://www.medrxiv.org/content/10.64898/2026.03.23.26347205v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.23.26347205v1.full-text
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Search Authors: Lucia Sanchez-Aranda Angel Toval Esmee A. Bakker Patricio Solis-Urra Isabel Martin-Fuentes Javier Fernandez-Ortega Rosa Maria Alonso-Cuenca Marcos Olvera-Rojas Beatriz Fernandez-Gamez Andrea Coca-Pulido Alberto Gonzalez-Garcia Dario Bellon Alessandro Sclafani Javier Sanchez-Martinez Ricardo Rivera-Lopez Norberto Herrera-Gomez Emilio J. Barranco-Moreno Francisco J. Amaro-Gahete Anna Carlen Jairo H. Migueles Danny J.J. Wang Kirk I. Erickson Eduardo Moreno-Escobar Rocio Garcia-Orta Irene Esteban-Cornejo Francisco B. Ortega, 

  Javilk's Research Links for Week 12
Updated 03/27/2026-11:59:04 PM
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