| Research Topics: |
| INDEX |
| AI-chat 2 |
| MCS 1 |
| PRIME 35 |
| aging 8 |
| brain 8 |
| cancer 11 |
| catastrophy 1 |
| climate 3 |
| cognition 4 |
| covid-19 3 |
| crime 7 |
| culture 2 |
| diabetes 3 |
| diagnostics 2 |
| drugs 2 |
| economy 1 |
| election 3 |
| energy 1 |
| exercise 3 |
| gender 1 |
| genetics 5 |
| gut 3 |
| heart 6 |
| humor 1 |
| immune 2 |
| lyme 1 |
| microbiome 3 |
| nutrition 2 |
| obesity 2 |
| pain 1 |
| physical 1 |
| politics 6 |
| pollution 1 |
| psychology 3 |
| quantum 1 |
| reproduction 2 |
| rights 1 |
| soc-media |
| space 1 |
| stress 1 |
| tech 3 |
| virus 1 |
|
Scanned: 1369 Evaluated: 235 Selected: 64 |
| IMMUNE | ||||||||
Mrh33-002 | A Functional FCGR2A Haplotype Associated with Rheumatoid Arthritis Determines Circulating Soluble FcRIIa Levels and Immune Complex Signalling | |||||||
| Quote: | Multi-omics analyses demonstrated that 2A.3 is associated with reduced expression of the soluble FCGR2A splice variant and lower circulating soluble Fc#947;RIIa levels. Functional studies revealed altered IgG interactions and delayed Fc#947;RIIa signal transduction associated with Q27W, while structural analyses found no evidence for stable ectodomain dimerisation. Together, these findings identify 2A.3 as an important functional contributor to RA susceptibility and provide mechanistic insight into how FCGR2A variation may influence immune regulation and disease risk in Europeans. | |||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.08.16.26360492v1 | |||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.08.16.26360492v1.full-text | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Euan W Baxter Eleanor G Foy John C Taylor Maren Thomsen Sina Bondza Simon Kolstoe Stephen Eyre span classnlm-collab data-hwp-idcollab-1BRAGGSS Consortium span classnlm-collab data-hwp-idcollab-2Yorkshire Early Arthritis Register Gerry Wilson John D Isaacs Paul Emery Javier Martin Mattia Frontini Tolulope Balogun span classnlm-collab data-hwp-idcollab-3NIHR BioResource Rare Diseases RNA Consortium Anne Barton Adrian Goldman Jenny H Barrett Ann W Morgan James I Robinson, | |||||||
| PRIME AGING BRAIN IMMUNE | ||||||||
Sd331-014 | Immune Cells Flood Into the Aging Brain, Stanford Scientists Discover | |||||||
| Quote: | Scientists have discovered that the aging human brain may be far less isolated from the rest of the body than once believed. Stanford researchers found that large numbers of immune cells from the blood begin entering the brain as early as middle age, where they can transform into microglia, the brains specialized immune cells. The finding overturns a long-standing assumption that these cells remain largely separate from the bodys immune system throughout life. | |||||||
| Article: | https://www.sciencedaily.com//releases/2026/08/260814011033.htm | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
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Javilk's Research Links Newsletter for Week 33 Updated 08/22/2026-02:37:36 AM What interests you? What have you found? Tell me! Drop me a note to subscribe or submit something. |