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METABOLISM
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Bmo39-009 | Dynamic protein phosphorylation shapes mitochondrial catalysis, import, and architecture |
| Quote: |
Most notably, we discover extensive phosphorylation on proteins
involved in mitochondrial cristae architecture, including multiple
members of the MICOS complex and ATP synthase, upon silencing the
phosphatase PGAM5. Collectively, our work connects reversible
phosphorylation and resident phosphatases to the regulation of diverse
mitochondrial processes.
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| Article:
| https://www.biorxiv.org/content/10.64898/2026.09.28.755151v1 |
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| Search Authors: |
Andrew J. Smith Patrick Forny Sean W. Rogers Merima Forny David J. Pagliarini,
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METABOLISM
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Mga39-002 | Causal relationship between liver fat reduction and clinical outcomes in human genetic studies and randomized clinical trials of metabolic-dysfunction associated steatohepatitis |
| Quote: |
These findings demonstrate the profound etiologic impact of liver fat
in MASH and provide compelling evidence for liver fat reductions as a
reasonably likely surrogate endpoint for future clinical development.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.09.27.26364101v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.09.27.26364101v1.full-text |
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Niek Verweij George Hindy Quang Nguyen Olukayode Sosina Kusha A Mohammadi Tejasv Bedi Joseph Herman Karl Landheer Benjamin Geraghty Selin Somersan-Karakaya Adam Locke Liron Ganel Arthur Gilly Rouel Lanche Stefanie Hectors Mary Germino Gavin H. Imperato Ifeanyi Anidi Lauryn Choleva Emily Labriola-Tompkins Muhammad Effendi Katie Tuckwell Sonya Aziz-Zaman Jane Witkin Jutta L Miller Tae-Hwi Schwantes-An span classnlm-collab data-hwp-idcollab-1Regeneron Genetics Center span classnlm-collab data-hwp-idcollab-2GHS-RGC DiscovEHR Collaboration span classnlm-collab data-hwp-idcollab-3Penn Medicine Biobank span classnlm-collab data-hwp-idcollab-4Colorado Center for Personalized Medicine span classnlm-collab data-hwp-idcollab-5Mayo Clinic-RGC Project Generation span classnlm-collab data-hwp-idcollab-6Malmo Diet and Cancer Study span classnlm-collab data-hwp-idcollab-7Indiana University School of Medicine (Indiana-CLDB) span classnlm-collab data-hwp-idcollab-8UCLA-RGC ATLAS Collaboration span classnlm-collab data-hwp-idcollab-9Mount Sinai Million Health Discoveries Program Rohit Loomba Naga P. Chalasani Rong Liu Mark Sleeman Viktoria Gusarova Gary A Herman Jonathan Marchini Aris Baras Thomas D Norton Luca A. Lotta David J Lederer,
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PRIME
GUT
METABOLISM
MICROBIOME
NUTRITION
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Sd395-016 | Mulberry May Reshape Gut Bacteria and Influence Metabolism |
| Quote: |
Mulberry has been eaten as food and used in traditional medicine for
centuries. Now, researchers are examining whether compounds in the
plant can alter the gut microbiota and, in turn, affect metabolism. A
review involving scientists from Wroclaw Medical University suggests
that the results may depend heavily on the mulberry species, which part
of the plant is used, and how it is processed. "The gut microbiota not
only contributes to the functioning of the gastrointestinal tract but
may also influence metabolism throughout the body.
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| Article:
| https://www.sciencedaily.com//releases/2026/09/260928100551.htm |
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