Research
Topics:
INDEX
AI-chat 3
PRIME 33
PRIO 3
aging 9
brain 14
brainwave 1
cancer 12
climate 4
cognition 3
covid-19 1
crime 2
culture 2
dental 2
diabetes 4
drugs 1
economy 4
election 3
energy 2
genetics 9
gut 1
heart 5
immune 6
law 1
metabolism 1
misc 2
nutrition 7
obesity 1
politics 5
pollution 4
practice 1
psychology 3
quantum 2
reproduction 2
rights 1
sleep 1
space 2
tech 4
vaccine 2
virus 3
war-confl
war-cyber 1
 
Scanned: 3392
Evaluated: 268
Selected: 71

 
Back Issue Map
    PRIME    PRIO    IMMUNE    NUTRITION   

Aee44-1053

Are Multivitamin Supplements a Waste of Money?

Quote: In this 2025 study researchers reported: "Regular MVM (multivitamin–multimineral) supplementation among older Taiwanese adults without prior MVM use could meaningfully reduce dementia burden and generate substantial healthcare and societal cost savings. These findings highlight regular MVM use as a pragmatic strategy to support cognitive health in aging populations...Regular MVM use was projected to prevent 204,250 dementia cases and 23,649 premature deaths.
Comment: Vitamins certainly helped me, kept me looking younger than people my age. The real question is how much do you really need? The Minimum Daily Adult Requirment is an absolute minimum for a healthy person. Illness often ramps up the need for specific vitamins, especially vitamin C.
Article: https://richardgoldberg.substack.com/p/are-multivitamin-supplements-a-waste
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    PRIME    CLIMATE   

Aef44-1001

New Study Suggests Warming Trend Might Be Delaying Next Ice Age

Quote: The findings in the Science study are also a coda for climate scientists who in the 1970s made the controversial claim that a new ice age was imminent. It actually was happening, Young says. They couldnt quite prove it, but now we sort of have the evidence. So, if these researchers are right, the carbon emissions that climate zealots want stopped appear to have halted, or at least put off, the next ice age. Shouldnt this be cause for celebration? And shouldnt we be encouraging everyone to keep burning as much fossil fuel as possible for as long as possible?
Comment: text=CO2 falls during an ice age. In the last ice age, CO2 levels ere about 180ppm, At 1between 150ppm and 130ppm land plants go extinct, and with that, all life on land and much in the sea goes with it.
Article: https://principia-scientific.com/weds-new-study-suggests-warming-trend-might-be-delaying-next-ice-age/
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See Also:
  • https://co2coalition.org/facts/dangerously-low-co2-last-four-glacial-advances/
  •     PRIME    PRIO    ECONOMY    ELECTION   

    Aeg44-1002

    Trump Is a Winner and Right on Iran

    Comment: Iran with nuclear bombs, or win the Elections? That was a hard leadership question that shows us Trump puts America far above himself....

    The difference between the old Soviet nuclear threat and Iranian one is simple. The soviets wanted their children and themselves to live. In contrast, Islam teaches martyrdom, AKA death in combat, is better than life. And their economy and life style tend to support that. With that background, there would not be much hesitation to use their nuclear bombs on the little Satan Israel, and the big Satan the USA.

    Quote: Considering everything we have witnessed from Iran, should anyone seriously trust this regime with a nuclear warhead? This is a government whose leaders have repeatedly threatened Israel and denounced America as the "Great Satan." Its hostility is not some theoretical concern. Those who suggest America is confronting Iran merely to serve Israels interests misunderstand the stakes. Remember Sept. 11: the terrorists did not attack skyscrapers in Tel Aviv. They attacked the World Trade Center in New York. We are the big target. Let me repeat: America is the real target.
    Article: https://www.newsmax.com/ruddy/donald-trump-iran-nuclear/2026/11/05/id/1275247/
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        PRIME    AGING    CANCER    GENETICS   

    Bcb44-009

    Polycomb Marked Promoter Methylation Gains in Aging and Cancer are Independent of Replication

    Quote: Together, these findings show that epigenetic trajectories during early tumor development, are rooted in baseline, age-dependent drivers of epigenetic alterations, and that oncogenic signaling acts primarily by selecting and expanding clones bearing pre-existing, age-associated epigenetic drift rather than instructing new methylation. Our findings have implications for how promoter methylation is interpreted as a cancer biomarker and for identifying upstream aging-associated processes as targets for early intervention.
    Article: https://www.biorxiv.org/content/10.64898/2026.10.30.763235v1
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    Search Authors: Hari Easwaran Sara-Jayne Thursby Nibedita Patel Zhicheng Jin Jacob Blum Shilpa Bisht Yong Tao Yuba Bhandari Daniel Petkovich Hisashi Ro Lijing Yang Jeff (Tza-Huei) R Wang Thomas Pisanic span classnlm-suffixII Stephen Bruce Baylin, 
        PRIME    GENETICS   

    Bgn44-017

    NanoPAMDA enables rapid PAM characterization of metagenome-derived Cas9 effectors

    Quote: CRISPR-Cas9 orthologs remain functionally underexplored despite the rapidly growing scale of publicly available metagenomic sequencing data. Here, we applied a multi-stage computational discovery pipeline to two independent sources of metagenomic sequence data, a multi-biome collection of 660,185 metagenome-assembled genomes spanning 17 public catalogs, and raw sequencing reads from human microbiome studies assembled de novo, to identify novel Cas9 orthologs.
    Article: https://www.biorxiv.org/content/10.64898/2026.11.04.764188v1
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    Search Authors: Ibrahim Genel Ceren Suren Ibrahim Cagri Kurt, 
        PRIME    IMMUNE   

    Bim44-011

    Decoding antibody-antigen recognition: the BL8 language and its application in calibrating deep learning predictions

    Quote: Using 15,396 experimental interface records from the Structural Antibody Database (SAbDab), we built a fixed reference atlas containing 1,498 discrete BL8 signatures. The atlas shows that natural interfaces occupy a diverse, long-tailed structural space in which similar geometric scaffolds can be associated with different chemical and sequence features. Furthermore, we projected 28,501 predicted complexes involving programmed death-ligand 1 (PD-L1), the SARS-CoV-2 receptor-binding domain (RBD), and programmed cell death protein 1 (PD-1), generated using AlphaFold 3 (AF3), Protenix-v2, and OpenDDE, into the reference space.
    Article: https://www.biorxiv.org/content/10.64898/2026.10.30.763264v1
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    Search Authors: Tingwei Miao Ruohan Zhu Ruiqi Lin Juncheng Qian Yi Feng Shuang Chen Yuxin Wang Daoyou Chen Yanling Wu Tianlei Ying, 
        PRIME    DRUGS    PRACTICE   

    Ps430-009

    The Epistemic Corruption of Biomedical Science

    Quote: One prominent exception is STS scholar Sergio Sismondo, who has written widely about how pharmaceutical companies built a vast, industry-controlled pipeline of knowledge production that underpins medical practice. He calls the result "epistemic corruption:" a knowledge system that "loses integrity, ceasing to provide the kinds of trusted knowledge expected of it," because it has been co#8209;opted by interests at odds with its central goals. Unlike bribery or vote-rigging, epistemic corruption arises from dense financial, organizational, and reputational dependencies linking universities, journals, regulators, clinicians, and industry all of it legal. Science thus becomes less an impartial arbiter of truth than part of a propaganda apparatus through which dominant actors frame problems, filter evidence, and orchestrate consent.
    Comment: Examples include Vitain C, Hydroxychloroquine, many other cheap and/or natural cures.
    Article: https://principia-scientific.com/the-epistemic-corruption-of-biomedical-science/ https://principia-scientific.com/the-epistemic-corruption-of-biomedical-science/https://principia-scientific.com/the-epistemic-corruption-of-biomedical-science/
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        PRIME    VACCINE   

    Ps430-010

    US Confidence In Covid Vaxxes During Pregnancy Continues to Plummet

    Article: https://principia-scientific.com/us-confidence-in-covid-vaxxes-during-pregnancy-continues-to-plummet/ https://principia-scientific.com/us-confidence-in-covid-vaxxes-during-pregnancy-continues-to-plummet/https://principia-scientific.com/us-confidence-in-covid-vaxxes-during-pregnancy-continues-to-plummet/
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        PRIME    CULTURE    POLITICS    PSYCHOLOGY   

    Ps430-015

    We Dont Need Algorithms to Prove Who Is Breaking the Rules

    Quote: They want you to be emotional. They want you to complain about the traffic, the view, or your feelingsbecause an emotional complaint is incredibly easy for an officer to dismiss with a patronising, templated apology. But when you strip away the emotion and present them with a targeted, legally sound question based on their own missing data, the machine breaks.
    Article: https://principia-scientific.com/we-dont-need-algorithms-to-prove-who-is-breaking-the-rules/ https://principia-scientific.com/we-dont-need-algorithms-to-prove-who-is-breaking-the-rules/https://principia-scientific.com/we-dont-need-algorithms-to-prove-who-is-breaking-the-rules/
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        PRIME   

    Ps443-002

    Where Are We in the Civilisation Cycle? What You Told Me

    Article: https://principia-scientific.com/where-are-we-in-the-civilisation-cycle-what-you-told-me/
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        PRIME    CRIME    WAR-CYBER   

    Ps443-003

    Cyber attack in seven European countries disables shop freezers

    Quote: Attackers remotely accessed internet-exposed refrigeration control systems (often older units with weak or unpatched security, default credentials, or insecure connections) and switched evaporators into defrost mode or directly raised set temperatures. Suppliers mentioned include Belgian firm Sabcobel and Danish firm Danfoss (linked to the earlier French incidents). The method closely matches the October French attacks.
    Article: https://principia-scientific.com/cyber-attack-in-seven-european-countries-disables-shop-freezers/
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        AI-CHAT    PRIME    CRIME   

    Ps443-009

    NIH-Funded Mad Scientists Have Created a Humanoid Robot

    Quote: Attackers remotely accessed internet-exposed refrigeration control systems (often older units with weak or unpatched security, default credentials, or insecure connections) and switched evaporators into defrost mode or directly raised set temperatures. Suppliers mentioned include Belgian firm Sabcobel and Danish firm Danfoss (linked to the earlier French incidents). The method closely matches the October French attacks.
    Comment: Indeed, this is disturbing
    Article: https://principia-scientific.com/nih-funded-mad-scientists-have-created-a-humanoid-robot/
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        PRIME    CLIMATE   

    Ps443-012

    Bombshell: New Climate Study Shows Zero Carbon Impact on Warming

    Quote: The crucial point is that fossil fuels are relatively depleted in carbon-13. If large quantities of fossil carbon are entering the atmosphere, one would expect their distinctive isotopic fingerprint to become apparent. The authors argue that it does not appear in the way the conventional explanation requires....

    Using their interpretation of the five-century historical record, they calculate a modern fossil contribution of approximately 1.3, effectively zero within their stated measurement uncertainty. The authors therefore go much further than suggesting that the IPCC has overestimated the contribution of fossil fuels.

    Article: https://principia-scientific.com/bombshell-new-climate-study-shows-zero-carbon-impact-on-warming/
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        PRIME    CLIMATE   

    Ps443-014

    What If Much of the Warming Is in the Thermometers?

    Quote: Before anyone can explain what caused global warming, there is a more fundamental question that must be answered: how accurately have we measured it?...

    His Chapter 11 contribution to Canary in a Climate World: Climate Realism vs. the Net Zero Myth challenges two foundations of the conventional climate narrative: The temperature record may contain substantial warming caused by urban development around weather stations. At the same time, the influence of the Sun may have been systematically understated.

    Article: https://principia-scientific.com/what-if-much-of-the-warming-is-in-the-thermometers/
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        PRIME    HEART   

    Sd430-003

    Scientists Discover a Hidden Driver of High Cholesterol and a Way to Stop It

    Quote: The process begins with a protein known as Ral, which Saltiel had previously investigated in fat cells. The team discovered that consuming high amounts of dietary cholesterol activates Ral, setting off a chain of events that leads to the loss of LDL receptors. As Ral activity increases, fewer receptors remain available to remove harmful cholesterol from the bloodstream. The researchers then identified another critical piece of the mechanism: an enzyme called cathepsin A (CTSA). This enzyme helps drive the process responsible for depleting LDL receptors. When scientists used a small molecule inhibitor to block CTSA, the results were striking.
    Article: https://www.sciencedaily.com//releases/2026/10/261030003003.htm
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        PRIME    CANCER    GUT   

    Sd430-004

    Scientists Finally Discover How a Common Gut Bacterium Can Trigger Colon Cancer

    Quote: The bacterium, Bacteroides fragilis, produces a toxin that damages the colons protective lining, triggers chronic inflammation, and promotes tumor formation.
    Article: https://www.sciencedaily.com//releases/2026/10/261031012912.htm
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        PRIME    DIABETES    NUTRITION   

    Sd443-001

    AI Helps Stanford Scientists Discover a Natural Ozempic with a Surprising Advantage

    Quote: Early animal experiments suggest that it can suppress appetite and promote fat loss much like semaglutide, the active ingredient in Ozempic, while potentially avoiding some of the drugs troublesome side effects. The molecule, known as BRP, works differently from existing treatments. Rather than affecting several organs throughout the body, it appears to act more selectively on a part of the brain responsible for controlling hunger and metabolism.
    Article: https://www.sciencedaily.com//releases/2026/11/261104004909.htm
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        PRIME    BRAIN    DIABETES    NUTRITION   

    Sd443-005

    Kids Who Eat More Ultra-processed Foods Show a Troubling Brain Response

    Quote: Children who consume more ultra-processed foods (UPFs) may have stronger brain responses to tempting foods, potentially helping explain why these products are associated with weight gain. A new study published in JAMA Network Open found that children who ate more of these foods showed heightened activity in the brains reward system when looking at pictures of appetizing foods. Those stronger responses were also associated with increases in body fat over the following year.
    Article: https://www.sciencedaily.com//releases/2026/11/261101010549.htm
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        PRIME    BRAIN    PSYCHOLOGY   

    Sd443-006

    The Brains Hidden Fear Mechanism May Explain Anxiety and PTSD

    Article: https://www.sciencedaily.com//releases/2026/11/261102202833.htm
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    See Also:
  • https://www.mcgill.ca/newsroom/channels/news/survival-mechanism-brain-may-help-explain-ptsd-375047
  •     PRIME    BRAIN    COGNITION    REPRODUCTION   

    Sd443-008

    Scientists Discover a Surprising Clue to Autisms Origins Hidden in the Placenta

    Quote: The researchers discovered that mouse fetuses were especially vulnerable when inflammation occurred 12.5 days into pregnancy. According to Irene Sanchez Martin, a postdoctoral researcher in Cheadles laboratory, approximately one-third of the fetuses showed developmental abnormalities within just 24 hours. Scientists have investigated the effects of maternal immune activation for decades, but these findings reveal signs of developmental disruption earlier than researchers had previously observed.
    Article: https://www.sciencedaily.com//releases/2026/11/261102202824.htm
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        PRIME    DIABETES    HEART    NUTRITION   

    Sd443-009

    Scientists Discover Surprising Heart Benefits of Eating Avocado and Mango Every Day

    Comment: Mango is related to poison ivy and poison oak. It can cause serious stomach irritation and temporary lack of absorption of nutrition. I know this from first hand experience. But Avocados can be quite good.
    Quote: In a study lasting just eight weeks, adults with prediabetes who regularly ate both fruits experienced improvements in blood vessel function and blood pressure, without gaining weight or consuming more calories.
    Article: https://www.sciencedaily.com//releases/2026/10/261031221215.htm
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        PRIME    BRAIN    COGNITION   

    Sd443-010

    Scientists Identify Two Overlooked Skills That Predict Reading Success

    Quote: Auditory processing involves recognizing and distinguishing the individual sounds that make up spoken words. For example, a child needs to identify the separate sounds within a word to understand how those sounds correspond to written letters. This skill helps support decoding, the process of working out how written words are pronounced. Comprehension-knowledge refers to the vocabulary, concepts and background information a child has accumulated through learning and everyday experiences. Having this foundation makes it easier to understand the meaning of words, sentences and longer passages.
    Comment: This makes a lot of sense. With my ears calibrated to a different language, as they say happens by age 4, I have always schtruggled with schpellink. Reading too, was difficult till suddenly, everything just clicked into place one day in second grade, surprising me.
    Article: https://www.sciencedaily.com//releases/2026/11/261102202845.htm
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        PRIME    AGING    BRAIN   

    Sd443-013

    Scientists Discover New Alzheimers Drug That Repairs DNA Damage and Reduces Brain Inflammation

    Quote: Their research suggests that an experimental drug originally developed for spinal cord injuries may help repair damaged DNA, reduce inflammation, and target biological changes associated with the disease. The drug, known as KCL-286, produced encouraging results in a mouse model of Alzheimers disease. Unlike treatments that focus primarily on the buildup of toxic proteins in the brain, this approach targets additional processes that can begin long before the disease reaches its advanced stages.
    Article: https://www.sciencedaily.com//releases/2026/11/261102075806.htm
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        PRIME    AGING    BRAIN   

    Sd443-014

    Scientists Reverse Liver Cell Aging and Cut Alzheimers-Linked Protein in Half

    Quote: Their research suggests that an experimental drug originally developed for spinal cord injuries may help repair damaged DNA, reduce inflammation, and target biological changes associated with the disease. The drug, known as KCL-286, produced encouraging results in a mouse model of Alzheimers disease. Unlike treatments that focus primarily on the buildup of toxic proteins in the brain, this approach targets additional processes that can begin long before the disease reaches its advanced stages.
    Article: https://www.sciencedaily.com//releases/2026/10/261031221155.htm
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        PRIME    PRIO    BRAIN    POLLUTION   

    Sd443-016

    Common Pesticide Linked to 2.5 Times the Risk of Parkinsons Disease

    Quote: Researchers at UCLA Health found that people with long-term residential exposure to chlorpyrifos, a widely used pesticide, had more than 2.5 times the risk of developing Parkinsons disease compared with those who were not exposed. Laboratory experiments also revealed how the chemical can interfere with the brains ability to remove damaged proteins, leading to the loss of nerve cells essential for controlling movement.
    Article: https://www.sciencedaily.com//releases/2026/10/261031013035.htm
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    See Also:
  • https://link.springer.com/article/10.1186/s13024-025-00915-z
  •     PRIME    CANCER    NUTRITION   

    Sd443-040

    Even Moderate Drinking Linked to Cancer and Early Death, Major Study Finds

    Quote: The findings suggest that alcohols risks begin at relatively low levels of consumption and increase as people drink more. "This study provides the most comprehensive U.S. estimates to date of lifetime risks of alcohol-attributable mortality and morbidity, showing that even moderate levels of consumption increase the risk of premature death and disability," said study co-author Katherine M. Keyes, PhD, professor of Epidemiology at Columbia University Mailman School of Public Health.
    Article: https://www.sciencedaily.com//releases/2026/10/261031221159.htm
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        PRIME    DENTAL   

    Sd444-006

    Goodbye, Cavities? Scientists Create Gel That Could Regrow Tooth Enamel

    Quote: Unlike conventional fluoride products, however, the new gel contains no fluoride. Instead, it uses a material made from proteins that imitates important characteristics of the natural proteins responsible for guiding enamel formation when teeth first develop. Once applied, the gel forms a thin but durable coating that penetrates the tooths surface and fills microscopic cracks and gaps. This coating then provides a framework for rebuilding the mineral structure of enamel.
    Article: https://www.sciencedaily.com//releases/2026/11/261104005059.htm https://www.sciencedaily.com//releases/2026/11/261104005059.htm/releases/2026/11/261104005059.htm
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        PRIME    BRAIN    CULTURE    POLITICS    PSYCHOLOGY   

    Sd444-012

    Permanent Daylight Saving Time Has a Dark Side, Scientists Warn

    Quote: Keeping daylight saving time in effect all year could bring brighter evenings, but new research suggests the change would come with a troubling consequence for American children. A nationwide switch could result in at least 2 billion additional trips to school in darkness, potentially increasing safety risks while reducing childrens exposure to important morning sunlight.
    Article: https://www.sciencedaily.com//releases/2026/11/261103003157.htm
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        PRIME    ECONOMY   

    Zze44-1003

    97-Year-Old Sues Toy Story Star Over 58 Gold Markups As Bankrupt Dealer Owes Customers 49 Million

    Quote: say former Disney star Erik von Detten talked them into putting 2.15 million of their retirement savings into overpriced gold coins worth only about 1.36 million at the time - a nearly 60 markup that left them with roughly 400 fewer ounces of gold than they would have gotten at spot prices....

    Roslands own first-day bankruptcy filing describes a dealer that took customer cash up front and waited to buy the metal later. As gold surged to record highs, customer orders backed up for months. "During this interval, the price of gold usually increased dramatically such that Debtor ended up paying more for the gold product than the customer paid Debtor for that product," the filing states. "This situation was not sustainable and the Debtor lost money rapidly." Sales reps still collected commissions of 15 to 35 of the gross profit on each order paid out as soon as the customers money arrived, even if the order was later canceled or never filled.

    Article: https://freedombunker.com/2026/11/02/97-year-old-sues-toy-story-star-over-58-gold-markups-as-bankrupt-dealer-owes-customers-49-million/
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        AI-CHAT    PRIME    ECONOMY    POLITICS   

    Zze44-1009

    The Soft Antichrist Of The AI Age: What Everyone Is Missing About The US-China Arms Race

    Quote: The more probable figure is not the one who promises safety. It is the one who promises growth. Most of the world does not lie awake about existential risk from machine intelligence. It lies awake about electricity, logistics, credit, tax collection, and a median citizen who is twenty four and needs work. To that world the universal offer is not a moratorium. It is a stack. Cheap. Financed. Hosted. Present. Already attached to the handsets, the ports, and the power. That is the soft Antichrist. It does not arrive with a speech about ending history. It arrives as the only AI that can grow your GDP.
    Comment: More knowlegeable people agree that current AI is just a well informed idiot unable to form significant concepts. Al this hoopla is premature.
    Article: https://freedombunker.com/2026/09/05/the-soft-antichrist-of-the-ai-age-what-everyone-is-missing-about-the-us-china-arms-race/
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        PRIME    CANCER    POLLUTION   

    Zze44-1056

    New Study Finds Paper Straws Worse For The Environment Than Plastic

    Quote: South Koreas Ministry of Climate, Energy and Environment, evaluated four types of straws conventional plastic, paper, biodegradable plastic, and bio-based polyethylene and their life-cycles in 16 different environmental categories. Conventional plastic straws had the smallest environmental impact in 10 of the 16 categories, including climate change, human toxicity, particulate matter, and acidification. Paper straws, meanwhile, had 6.33 times the carcinogenic impact of standard plastic straws, plus twice as much impact on acidifying the environment, according to the study. Meanwhile, biodegradable plastic straws had 3.34 times the carcinogenic impact and 1.98 times the acidification impact of conventional plastic straws, the study found. As for bio-based polyethylene straws made from renewable materials like sugarcane they produced 16 times the carcinogenic impact of conventional plastic straws, and six times the acidification damage, a measure of changes in ocean and soil pH.
    Article: https://principia-scientific.com/new-study-finds-paper-straws-worse-for-the-environment-than-plastic/
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        PRIME    ECONOMY    ELECTION    POLITICS   

    Zzf44-1004

    Why Is a Man Accused of Fraud in Two Countries Helping Run Election Machines?

    Quote: Whether fraud significantly impacted results in Texas or any other state, I do not know. Election integrity advocate Lara Logan, who highlighted Garcia, has been speaking with analysts who believe it did. But we only know two things for certain right now. First, the Trump administration has released a good deal of evidence that election machines are vulnerable and susceptible to hacks and manipulation from malicious actors, both foreign and domestic. Second, I dont think we should trust a company that hires someone accused multiple times over of illicit activities related to elections. That should be true regardless of whether fraud actually occurred in 2026.
    Article: https://pjmedia.com/catherinesalgado/2026/11/05/why-is-a-man-accused-of-fraud-in-two-countries-helping-run-election-machines-n4959074
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        PRIME    ELECTION    POLITICS   

    Zzf44-1010

    20 Million New Voter Registrations in States Without Citizenship Proof

    Quote: According to the viral analysis, nearly 20 million new voter registrations occurred between 2022 and 2024 in states that did not require documentary proof of citizenship. The controversy has reignited debate over the SAVE America Act, which would establish stricter citizenship verification requirements for federal voter registration.
    Article: https://pjmedia.com/phone-kyaw/2026/11/06/26-million-new-voter-registrations-in-states-without-citizenship-proof-n4959110
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      Javilk's Research Links Newsletter for Week 44
    Updated 11/06/2026-10:26:45 PM
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