| Research Topics: |
| INDEX |
| AI-chat 3 |
| PRIME 33 |
| PRIO 3 |
| aging 9 |
| brain 14 |
| brainwave 1 |
| cancer 12 |
| climate 4 |
| cognition 3 |
| covid-19 1 |
| crime 2 |
| culture 2 |
| dental 2 |
| diabetes 4 |
| drugs 1 |
| economy 4 |
| election 3 |
| energy 2 |
| genetics 9 |
| gut 1 |
| heart 5 |
| immune 6 |
| law 1 |
| metabolism 1 |
| misc 2 |
| nutrition 7 |
| obesity 1 |
| politics 5 |
| pollution 4 |
| practice 1 |
| psychology 3 |
| quantum 2 |
| reproduction 2 |
| rights 1 |
| sleep 1 |
| space 2 |
| tech 4 |
| vaccine 2 |
| virus 3 |
| war-confl |
| war-cyber 1 |
|
Scanned: 3392 Evaluated: 268 Selected: 71 Back Issue Map |
| PRIME AGING CANCER GENETICS | |||||||||||||||||||
Bcb44-009 | Polycomb Marked Promoter Methylation Gains in Aging and Cancer are Independent of Replication | ||||||||||||||||||
| Quote: | Together, these findings show that epigenetic trajectories during early tumor development, are rooted in baseline, age-dependent drivers of epigenetic alterations, and that oncogenic signaling acts primarily by selecting and expanding clones bearing pre-existing, age-associated epigenetic drift rather than instructing new methylation. Our findings have implications for how promoter methylation is interpreted as a cancer biomarker and for identifying upstream aging-associated processes as targets for early intervention. | ||||||||||||||||||
| Article: | https://www.biorxiv.org/content/10.64898/2026.10.30.763235v1 | ||||||||||||||||||
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| Search Authors: | Hari Easwaran Sara-Jayne Thursby Nibedita Patel Zhicheng Jin Jacob Blum Shilpa Bisht Yong Tao Yuba Bhandari Daniel Petkovich Hisashi Ro Lijing Yang Jeff (Tza-Huei) R Wang Thomas Pisanic span classnlm-suffixII Stephen Bruce Baylin, | ||||||||||||||||||
| AGING HEART | |||||||||||||||||||
Bpa44-004 | Pharmacological activation of mitophagy prevents calcific aortic valve disease by targeting dysregulated mitochondrial-to-nuclear communication | ||||||||||||||||||
| Quote: | Conclusions: Mitophagy impairment drives CAVD through dysregulated mitochondrial-to-nuclear communication mediated by the MCL1-PRMT3-BACH1-PARM1 axis. Pharmacological mitophagy activation by TJ0113 corrects this communication and attenuates disease progression, representing a promising therapeutic strategy for CAVD. | ||||||||||||||||||
| Article: | https://www.biorxiv.org/content/10.64898/2026.10.31.763012v1 | ||||||||||||||||||
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| Search Authors: | Dao Zhou Hanyi Dai Junhao Qiu Yihan Pan Wangxing Hu Hongyu Lu Junhui Xue Haochang Hu Dilin Xu Jingling Dai Jin Lu Shuangshuang Yang Ningjing Qian Yufei Li Si Cheng Ziling Mai Jiaqi Fan Qifeng Zhu Yuchao Guo Yuxin He Jinghai Chen Hongguang Xia Jianan Wang Xianbao Liu, | ||||||||||||||||||
| Search Words: |
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| PRIME AGING BRAIN | |||||||||||||||||||
Sd443-013 | Scientists Discover New Alzheimers Drug That Repairs DNA Damage and Reduces Brain Inflammation | ||||||||||||||||||
| Quote: | Their research suggests that an experimental drug originally developed for spinal cord injuries may help repair damaged DNA, reduce inflammation, and target biological changes associated with the disease. The drug, known as KCL-286, produced encouraging results in a mouse model of Alzheimers disease. Unlike treatments that focus primarily on the buildup of toxic proteins in the brain, this approach targets additional processes that can begin long before the disease reaches its advanced stages. | ||||||||||||||||||
| Article: | https://www.sciencedaily.com//releases/2026/11/261102075806.htm | ||||||||||||||||||
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| PRIME AGING BRAIN | |||||||||||||||||||
Sd443-014 | Scientists Reverse Liver Cell Aging and Cut Alzheimers-Linked Protein in Half | ||||||||||||||||||
| Quote: | Their research suggests that an experimental drug originally developed for spinal cord injuries may help repair damaged DNA, reduce inflammation, and target biological changes associated with the disease. The drug, known as KCL-286, produced encouraging results in a mouse model of Alzheimers disease. Unlike treatments that focus primarily on the buildup of toxic proteins in the brain, this approach targets additional processes that can begin long before the disease reaches its advanced stages. | ||||||||||||||||||
| Article: | https://www.sciencedaily.com//releases/2026/10/261031221155.htm | ||||||||||||||||||
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| AGING BRAIN OBESITY | |||||||||||||||||||
Sd443-037 | Extra Weight May Be Aging Your Brain Faster Than You Think | ||||||||||||||||||
| Quote: | To investigate the connection, the research team analyzed data from a nationally representative study that tracked more than 8,200 adults over age 50 for 24 years. Higher BMI Linked to Faster Cognitive Decline The results revealed a consistent relationship between body weight and cognitive health. Each one-point increase in BMI was associated with a faster rate of cognitive decline, suggesting that even relatively small differences in body weight could matter over time. | ||||||||||||||||||
| Article: | https://www.sciencedaily.com//releases/2026/11/261101010559.htm | ||||||||||||||||||
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| AGING HEART NUTRITION | |||||||||||||||||||
Sd443-038 | Experts Say High Blood Pressure Guidelines Are Missing Half the Equation | ||||||||||||||||||
| Quote: | Researchers say that increasing potassium intake, rather than focusing only on reducing sodium, could lead to better blood pressure control. By addressing both nutrients together, this approach could strengthen efforts to prevent hypertension and reduce the risk of serious cardiovascular problems. | ||||||||||||||||||
| Article: | https://www.sciencedaily.com//releases/2026/11/261102075553.htm | ||||||||||||||||||
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| AGING BRAIN | |||||||||||||||||||
Sd444-001 | An Anti-aging Drug May Help Protect the Brain Before Alzheimers Symptoms Begin | ||||||||||||||||||
| Quote: | A drug commonly used to prevent organ transplant rejection may offer an unexpected new approach to protecting people at increased risk of Alzheimers disease. Researchers at the University of Missouri have discovered that rapamycin, a medication also studied for its effects on aging, can improve blood flow in the brains of middle-aged adults who carry a gene variant linked to Alzheimers. | ||||||||||||||||||
| Article: | https://www.sciencedaily.com//releases/2026/11/261104084017.htm | ||||||||||||||||||
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| AGING BRAIN BRAINWAVE COGNITION | |||||||||||||||||||
Sd444-005 | Scientists Discover Mysterious Lonely Brain Waves Linked to Memory Loss | ||||||||||||||||||
| Quote: | . Neuroscientist Omer Sharon and his colleagues, working under the direction of former Berkeley sleep researcher Matthew Walker, discovered a connection between disrupted brain waves during deep sleep, declining memory performance, and the accumulation of tau, a protein associated with Alzheimers disease. The findings suggest that tau buildup in the brains frontal cortex is linked to changes in the coordinated electrical activity that helps preserve memories overnight. "This is the first time weve shown this relationship between tau and how it messes with memory consolidation by attenuating traveling slow waves that originate in the frontal cortex," | ||||||||||||||||||
| Article: | https://www.sciencedaily.com//releases/2026/11/261101010556.htm | ||||||||||||||||||
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| AGING | |||||||||||||||||||
Sd444-010 | A Surprising Discovery Could Help Aging Muscles Repair Themselves | ||||||||||||||||||
| Quote: | At the higher concentration, LASSS did much more than protect HGF from chemical damage. It also dramatically improved the proteins ability to bind to its receptor. Compared with untreated HGF, the protein exposed to LASSS showed more than twice the binding affinity for c-met. In other words, it could attach to its target receptor much more strongly, potentially enhancing a critical step in the muscle repair process. | ||||||||||||||||||
| Article: | https://www.sciencedaily.com//releases/2026/11/261104005226.htm https://www.sciencedaily.com//releases/2026/11/261104005226.htm/releases/2026/11/261104005226.htm | ||||||||||||||||||
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Javilk's Research Links Newsletter for Week 44 Updated 11/06/2026-10:26:45 PM Back Issue Topic Map What interests you? What have you found? Tell me! Drop me a note at Javilk.com to subscribe or submit something. |