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Bcb44-007

ANABOLIC FAILURE, NOT CATABOLIC ACTIVATION, UNDERLIES GLYCOGEN DEPLETION IN CERVICAL CARCINOGENESIS: A MULTI-COHORT TRANSCRIPTOMIC ANALYSIS

Quote: Conclusions. Glycogen depletion in cervical carcinogenesis reflects failure of a tissue-restricted synthetic axis, GYS2 and PPP1R3C, within a collapsing squamous differentiation program, not catabolic activation. Measuring all four candidate mechanisms on one scale in the same specimen is what allows the catabolic explanation to be excluded rather than merely left untested. The pattern holds across two array chemistries and three specimen preparations, including the exfoliated cytology that screening already collects, and the synthesis and differentiation modules together are the molecular counterpart of what iodine staining reports. These are transcript-level findings and define no clinical threshold.
Article: https://www.biorxiv.org/content/10.64898/2026.11.02.763436v1
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Search Authors: Oyedele Oyewumi Ajayi Efosa Bolaji Odigie Samson Oluwaseyi Adesite Theophilus Erameh Anietie Michael Archibong Uchechukwu Brian Eziagu, 
    PRIME    BRAIN    COGNITION    REPRODUCTION   

Sd443-008

Scientists Discover a Surprising Clue to Autisms Origins Hidden in the Placenta

Quote: The researchers discovered that mouse fetuses were especially vulnerable when inflammation occurred 12.5 days into pregnancy. According to Irene Sanchez Martin, a postdoctoral researcher in Cheadles laboratory, approximately one-third of the fetuses showed developmental abnormalities within just 24 hours. Scientists have investigated the effects of maternal immune activation for decades, but these findings reveal signs of developmental disruption earlier than researchers had previously observed.
Article: https://www.sciencedaily.com//releases/2026/11/261102202824.htm
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  Javilk's Research Links Newsletter for Week 44
Updated 11/06/2026-10:26:45 PM
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