Following the Money Written by John Campbell

Following the money Gus described how he went digging. Scientists in Wuhan, he said, had already published work in major journals describing the kind of genetic inserts he and Srensen had flagged. Many of those papers carried the name of the American virologist Ralph Baric, whom Gus credits with pioneering techniques for stitching viral RNA together without leaving a trace. When Gus raised this, he said, a member of the Royal Society told him it could not be done. Two things stood out in the small print: funding routed through Peter Daszaks EcoHealth Alliance, and grants from the US National Institute of Allergy and Infectious Diseases, then led by Anthony Fauci. That led Gus to the Nature Medicine paper, "The proximal origin of SARS-CoV-2", which he believes was organised to close down the lab-leak debate. Reading it, he said, he found that its own references could be used to argue the opposite of its conclusion. "It was like a Guardian article," he said, "where the headlines completely the opposite of whats in it." The paper was then used against him.

A scalable invariant causal discovery framework reveals direct genetic and clinical determinants of complex human traits

Cross-ancestry proteome-wide Mendelian randomization of plasma proteins and breast cancer susceptibility

Single-Cell Transcriptome-Wide Mendelian Randomization and Colocalization Analysis Reveals Immune Cell-Specific Mechanisms in Alzheimers Disease

A multi-center retrospective chart analysis identifying clinical, biochemical, and radiographic signatures of short-chain enoyl-CoA hydratase (ECHS1) deficiency

Of note , the reported ability of some patients with ECHS1D to tolerate ketogenic diet highlights that it is likely the impaired amino acid catabolism and not the impaired fatty acid oxidation defect that contributes to disease, although the data remain limited. These findings highlight that ECHS1D represents a spectrum disease, with limited genotype-phenotype correlation, contribu ting to variability in outcomes. Nonetheless, families and providers often seek prognostic information in the face of a challenging and rare diagnosis. Therefore, cat egorization by age of onset does seem to be a meaningful way to provide insight on predicted morbidity and mortality.

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