Research
Topics:
INDEX
AI-chat 11
MCS 1
PRIME 33
PRIO 4
aging 9
arthritis 5
body 3
brain 4
brainwave 2
cancer 15
climate 1
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crime 5
culture 1
dental 6
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drugs 3
ears 2
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emergency 1
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gender 1
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immune 12
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law 2
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lyme 1
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physical 7
politics 3
pollution 3
practice 4
psychology 7
quantum 2
reproduction 7
rights 1
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space 3
tech 2
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virus 3
war-confl
 
Scanned: 2960
Evaluated: 607
Selected: 131

 
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    AGING    GENETICS    IMMUNE   

Mge45-002

Single-Cell Transcriptome-Wide Mendelian Randomization and Colocalization Analysis Reveals Immune Cell-Specific Mechanisms in Alzheimers Disease

Article: https://www.medrxiv.org/content/10.64898/2026.11.03.26367234v1
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Search Authors: Youwei Si Youwen Si, 
    IMMUNE   

Mim44-003

Patient Trajectories from Electronic Health Records Suggest Specialty Specific Warning Signs for Common Variable Immunodeficiency

Quote: Conclusions Individuals referred to Allergy / Immunology have shorter time to diagnosis, and a specialty-specific prediction could improve detection of common variable immunodeficiency. Clinical Implications Overall, we find that phenotype-specialty interactions may inform targeted interventions to improve common variable immunodeficiency recognition across specialties, reducing diagnostic odyssey and disease-related complications.
Article: https://www.medrxiv.org/content/10.64898/2026.10.01.26364525v1
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Search Authors: Rachel Mester Aaron T. Chin Veronica Tozzo Alexis V. Stephens Hal M. Hoffman Marc A. Reidl Morna J. Dorsey Sudhir Gupta Yesim Y. Demirdag Sriram Sankararaman Lisa Bastarache Bogdan Pasaniuc Manish J. Butte, 
    IMMUNE    LUNGS   

Mim44-011

Divergent Eosinophilic and Paradoxical Inflammatory Adverse-Event Signatures Across Five Type 2 Asthma Biologics: A FAERS Active-Comparator Disproportionality Analysis

Quote: Conclusion FAERS active-comparator analysis reveals drug-specific, not class-uniform, adverse-event reporting patterns: anti-IL-5-axis agents disproportionately report EGPA/vasculitis, and dupilumab disproportionately reports ocular inflammation with markedly earlier onset. These hypothesis-generating signals cannot establish causality and require confirmation through case-level or comparative pharmacoepidemiological studies.
Article: https://www.medrxiv.org/content/10.64898/2026.09.21.26363575v1
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Search Authors: Adalia Cristiana Iancu Marwan Kobtan Nada Soliman Shahinazhanem Abdellatif, 
    HEART    IMMUNE   

Mrh44-003

Wide-angled proteomics in giant cell arteritis reveals complement pathway activation

Quote: Giant cell arteritis (GCA) is an immune-mediated vasculitis that can cause serious morbidity including sight loss, stroke and aortic aneurysm....

Our data implicate terminal complement pathway activation in GCA, raising the possibility of complement-directed therapies. We show proof-of-principle that a multiplex protein biomarker could be used as a diagnostic adjunct in suspected GCA.

Article: https://www.medrxiv.org/content/10.64898/2026.10.14.26365544v1
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Search Authors: Benjamin J. Whittle Martina Williams Hannah Lomax-Browne Louise Sorensen Robert T. Maughan Matthew Porteous Aruna Chakrabarty Raashid A. Luqmani Matthew C. Pickering Ann W. Morgan James E. Peters, 
    ARTHRITIS    IMMUNE    PHYSICAL   

Mrh44-005

Combining A Massively Parallel Reporter Assay and Human Data to Elucidate Genetic Mechanisms Driving Risk for Juvenile Idiopathic Arthritis

Quote: Results SNPs identified on MPRA were associated with gene expression levels in a broad range of immune cells in the DICE database, including CD4 and CD8 T lymphocytes, monocytes, NK cells, and B cells. MPRA-identified SNPs showed strong associations with gene expression in GTEx whole blood, spleen, and/or EBV-transformed lymphocytes.
Article: https://www.medrxiv.org/content/10.64898/2026.08.24.26361225v2
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Search Authors: Kaiyu Jiang Susan Kales Ryan Tewhey James N. Jarvis, 
    ARTHRITIS    IMMUNE   

Mrh44-007

PROTEOMIC IDENTIFICATION OF NOVEL AUTOANTIBODY TARGETS IN RHEUMATOID ARTHRITIS AND DIAGNOSTIC PERFORMANCE OF TGF-1-INDUCED PROTEIN AND SERUM AMYLOID A AUTOANTIBODIES

Quote: Conclusion RA sera contain autoantibodies targeting multiple proteins associated with the TGF-#946;1 signaling pathway that is implicated in inflammatory processes in RA. Among the candidates tested, TGFBI and SAA autoantibodies exhibited the highest diagnostic performance in a POC lateral-flow format, supporting their potential utility as biomarkers for RA diagnosis. These findings also support further investigation of the TGF-#946;1 signaling pathway as a potential therapeutic target in RA.
Article: https://www.medrxiv.org/content/10.64898/2026.09.25.26361099v2
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Search Authors: Melissa Frenchmeyer Michael Moleski Allison Keilman Stephanie Fernandez Kilsun Kim Keith Zientek Phillip Wilmarth Ashok Reddy Lina Gao Vishnupriya R. Paturi Charles T. Roberts Srinivasa R. Nagalla, 
    PRIME    ARTHRITIS    IMMUNE   

Mrh44-010

Diabetes related antibody signature highlights ZnT8 as a novel antigenic target in rheumatoid arthritis

Quote: Objective Autoantibodies are central for pathology of rheumatoid arthritis (RA) and diabetes mellitus (DM) carrying high predictive and diagnostic value. Here, we explore the frequency and functional potential of DM-related antibodies (DMab) in RA.
Article: https://www.medrxiv.org/content/10.64898/2026.09.25.26364002v1
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Search Authors: Malin C. Erlandsson Venkataragavan Chandrasekaran Elena Neumann Yuang Zhang Malak Y.H. Alsoofi Sofia T. Silfverswrd Cristina Maglio Ulf Muller-Ladner Rille Pullerits Maria I. Bokarewa, 
    PRIME    ARTHRITIS    IMMUNE   

Mrh45-026

Screening for rheumatoid arthritis-associated interstitial lung disease using lung ultrasound: a systematic review and meta-analysis of recent studies

Quote: Numerous studies have proven lung ultrasounds (LUS) utility in ILD, as well as other lung pathologies. Recently, there has been more focus on ILD in rheumatoid arthritis (RA), a previously overlooked complication, and screening methods. The purpose of this systematic review and meta-analysis was to summarize the recent knowledge regarding LUS compared to HRCT in screening ILD in RA patients.
Article: https://www.medrxiv.org/content/10.64898/2026.11.02.26365310v2
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Search Authors: Armin Dan Copoeru Mihaela Mocan Anca Farcas Sonia Vlaicu Romeo Ioan Chira, 
    EXERCISE    IMMUNE   

Msm45-013

Exercise reshapes cellular immunity toward anti-inflammation and diminishes CCR4 levels on LFA-1#945;highCD4 T cells in multiple sclerosis

Article: https://www.medrxiv.org/content/10.64898/2026.11.05.26367365v1
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Search Authors: Sebastian Proschinger Tiffany Wences Chirino Leon Hoenen Sina Trebing Niklas Joisten David Walzik Niklas Daube Gisa Ellrichmann-Wilms Shiva Ahmadi Martin Schneider Piotr Zadora Dario L. Frey Sven G. Meuth Marc Pawlitzki Lars Masanneck Jens Kuhle Tobias Ruck Robert Rehmann Alessa L. Henneberg Christiane A. Opitz Philipp Zimmer, 
    PRIME    CANCER    DRUGS    IMMUNE    NUTRITION   

Ps446-013

What Fenbendazole and Ivermectin Have in Common with a Cure

Quote: And the fact that these low-cost, off-patent drugs are dismissed so aggressively raises an important question: Is this about science, or about profit? That question runs through everything in this article. Because whether we are talking about a 5 dog dewormer, a daily walk in the sunshine, or a natural hormone your body makes, the pattern is the same: If it cant be patented, it gets buried.
Comment: Several effective anti-cancer treatments listed.
Article: https://principia-scientific.com/what-fenbendazole-and-ivermectin-have-in-common-with-a-cure/
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    PRIO    IMMUNE   

Ps446-014

Americas Overreliance on Antibiotics Is Fueling Drug-Resistant Infections

Quote: The report released Tuesday ranks 19 drug-resistant threats, and found that infections common among hospital patients account for more than 42,000 of the deaths and more than 12 billion in costs. U.S. pharmacies filled 255.9 million outpatient antibiotic prescriptions in 2024, or 752 for every 1,000 Americans, according to CDC data. agency estimates at least 28 percent of antibiotics prescribed in doctors offices and emergency departments are unnecessary, many of them written for colds, bronchitis and other viral illnesses that antibiotics cannot treat.
Article: https://principia-scientific.com/americas-overreliance-on-antibiotics-is-fueling-drug-resistant-infections/
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    IMMUNE    NUTRITION   

Sd451-007

Common Supplement Could Help Fight Psoriasis, Scientists Discover

Quote: Scientists have discovered that pantethine, a readily available vitamin B5 derivative, can calm overactive immune cells and may help fight psoriasis. The supplement prevented psoriasis in mice and showed promising results in a small human trial, revealing an unexpected connection between cholesterol and autoimmune inflammation.
Article: https://www.sciencedaily.com//releases/2026/11/261108233057.htm
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  Javilk's Research Links Newsletter for Week 45
Updated 11/14/2026-03:15:39 AM
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